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Catalog# Product Description |
ICP6031 These antibodies were tested with human and mouse cell lysates and mouse tissue (brain) extracts to detect Jun NH2-terminal kinases (JNKs). JNK has a molecular weight ranging from 38-56 kDa, which is masked up by the IP IgG bands. Tests using the HRP conjugated anti-JNK do not require secondary Ab, eliminating interference from IgG bands. |
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Western blot analysis of mouse brain extract with ICP6030
A: Extract from control hypoxia mouse brain
B: Extract from control mouse
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Species
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Rabbit
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Formulation
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250 μg/mL in HRP stabilizing buffer with 50% glycerol
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Immunogen
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Human JNK1 (acetylated KLH conjugates)
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Purification
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The antibody was purified by peptide-affinity chromatography.
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Conjugation
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Reductive amination; HRP/Ab molar ratio - 10:1
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Specificity
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The recognition sequence in human and mouse is identical to JNK3, JNK2, and JNK1.
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Applications
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ELISA (1:1000); WB (1:1000)
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Scientific Description
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Jun NH2-terminal kinase (JNK) is a member of the mitogen-activatedprotein kinase family, which plays a central role in the regulationof cellular differentiation and proliferation. It also participatesin the regulation of IL-2 and IL-2 receptor gene expression. Over-activation of the c-JNK induces cell death.
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Storage & Stability
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Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is six months from date of shipping if stored properly.
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Product Specific References
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